Postdoctoral Scholar
College of Medicine
6h ago


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A NIH-funded Postdoctoral position is available in Dr. Shengyu Yang’s lab at the Penn State College of Medicine to study the role of mitochondrial metabolism in cancer metastasis.

Our goal is to reveal how the dysregulated actin cytoskeleton in metastatic cancer cells controls mitochondrial oxidative phosphorylation by remodeling the mitochondrial actin filaments.

This project is built on our recent discoveries that the actin cytoskeleton remodeling in metastatic cancer cells is able to control mitochondrial metabolism through regulating the homeostasis of mtDNA and the biogenesis of mitochondrial respiratory chain.

Please see our recent publications for more information (Lin et al, 2019, Cell Reports, PMID : 31509745; Lin et al, 2019, EMBO Mol Med, PMID : 31633874).

Biochemistry, cell biology, live cell imaging techniques, genetically engineered mouse models and patient-derived organoids / xenografts will be employed in the study.

Successful applicant will :

  • Be a highly motivated recent graduate
  • Have a Ph.D. or equivalent degree
  • Have expertise in cell biology, biochemistry, molecular biology or related fields.
  • Experience with fluorescence imaging, super-resolution microscopy and genetically engineered mouse models will be desirable but not required.

    The research in Dr. Yang’s lab is well funded by grants from the National Cancer Institute, Department of Defense and the Elsa U.

    Pardee Foundation. The Penn State College of Medicine Campus is located in Hershey, PA. Hershey is a quiet, family friendly town with an affordable living expense and easy access to major metropolitan areas (e.

    g. Philadelphia, Washington DC, New York City).

    Please upload :

  • Cover Letter
  • Contact Information for Three References.
  • Lab webpage :

    The following background checks must be successfully completed for this position :

    This position will require successful completion of standard background checks.

  • Pennsylvania State Police Criminal Background Check
  • Pennsylvania Child Abuse History
  • Federal Bureau of Investigation (FBI) Criminal Background Check
  • The Pennsylvania State University is committed to and accountable for advancing diversity, equity, and inclusion in all of its forms.

    We embrace individual uniqueness, foster a culture of inclusive excellence that supports both broad and specific diversity initiatives, leverage the educational and institutional benefits of diversity, and engage all individuals to help them thrive.

    We value inclusive excellence as a core strength and an essential element of our public service mission.


    Pursuant to the Jeanne Clery Disclosure of Campus Security Policy and Campus Crime Statistics Act and the Pennsylvania Act of 1988, Penn State publishes a combined Annual Security and Annual Fire Safety Report (ASR).

    The ASR includes crime statistics and institutional policies concerning campus security, such as those concerning alcohol and drug use, crime prevention, the reporting of crimes, sexual assault, and other matters.

    The ASR is available for review .

    Penn State is an equal opportunity, affirmative action employe

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